Clinical trial supply chain forecasting & risk management optimization

The Challenge

Predict the unpredictable in increasingly complex trials

Over the course of supplying a clinical study, factors such as drop-out rate, enrollment speed and sites/countries involved can change rapidly. Highly unpredictable demand translates into a lot of uncertainty and high costs to cover the worst case. Shorter shelf lives, expensive comparator and limited production capacity for biopharmaceuticals make it even more complicated to put in place a robust supply strategy.

Managing changes in this complex situation while at the same time controlling the risk of drug not being available on-site for patient dispensing can be a stressful challenge for clinical supply teams.

The Solution

Design, Plan and Monitor
Clinical Trial Supply

N-SIDE CT-FAST end-to-end clinical trial supply chain solution supports clinical trial supply chain managers to get the right drug to the right place at the right time and at lowest costs!  

Get support for strategic to operational decisions using advanced simulation and optimization technologies. With CT-FAST design, plan, and monitor your clinical trial with ease – no more firefighting!

DESIGN
Support Clinical Directors in key strategic decisions

Increase collaboration between clinical and supply teams during protocol finalization with quantified simulations reports.  With N-SIDE CT-FAST Solution, the impact of early decisions, such as packaging design, can be quantified.  Having these results facilitates strategic decision making and significantly improves cross-department communication.

PLAN
Match supply to patient demand with optimal resupply rules

By optimizing the supply strategy based on all specificities of the trial design, production planning is tuned to meet the demand and required overage to manage the risk. Prepare for the unforeseen with advanced algorithms testing multiple “what if” scenarios. By running thousands of simulations for each scenario, assess the impact of such potential changes as different enrollment rates, drop-out rates and changes to the country list. Equipped with CT-FAST results, you can schedule your production plan and set up your IRT based on accurate forecasts robust to change.

 

MONITOR
Leverage live IRT data to manage the unexpected

Manage the risk with up-to-date forecasts and adapt production plan & depot resupply strategy real-time. Both data from the IRT provider and updated study assumptions are taken into account with an appropriate weight.  This allows the supply team to easily consider the past and to plan accurately for the future.

CT-FAST software solution integrates with any IRT systems.  Its user friendly interface and dynamic Business Intelligence dashboards facilitate your decision making. Combined with expert advice and advanced reporting provided by our consultants, your team has all the tools in hand to design, plan and monitor an optimal supply strategy.

From using CT-FAST in-house with a yearly license to receiving CT-FAST results through N-SIDE consulting services, there is a range of CT-FAST deployment possibilities. Together we can tailor a custom mix of software access and consulting services to meet your needs.

Originally designed together with one of the top 20 pharmaceutical company, N-SIDE  CT-FAST solution is now optimizing clinical trial supply worldwide for more than 15 years!

Risk management

pinpoint where and when risk could occur to identify actions to ensure no patient will miss a dispensing visit

Network design

assess the impact of adding or removing local depots and countries to your trial

Depot management

manage the risk coming from your local depots with robust simulation results providing your resupply strategy with the required quantities and shipment dates

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Demand planning

forecast your trial needs taking into account the variability inherent to clinical studies

Budget planning

evaluate the impact of different supply scenarios on your trial budget regarding fixed and variable costs

Inventory management

know how much stock will be required at each site according to your supply chain strategy. Especially critical for cold chain products

The Results

Agile and optimized end-to-end supply chain

From specialized Biotech with a few trials per year to the largest pharmaceutical companies, CT-FAST optimizes your clinical trial strategies, strengthens your agility. 

$

Proactively mitigate 100% of the risk of your patients missing a dose

$

Set up your IRT to best fit your trial specificities

$

Anticipate trial changes & adapt your supply strategy quickly

$

Improve collaboration between supply managers, clinical managers and project leaders

$

Reduce product waste by up to 40%

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Decrease supply costs on average up to 30%

scenario comparisons per trial

simulations run per strategy

trials per year

— They trust us —

quote-testimonials

Sanofi

Sanofi
“In a VUCA (volatility, uncertainty, complexity and ambiguity) world, simulations and forecasting are creating a tactical clinical supply chain, ensuring that each patient gets their medication on time”.

Didier Basseras, Vice-President of Clinical Supplies, Sanofi.

— They trust us —

quote-testimonials

roche

Roche
With CT-FAST, Roche has been able to reduce overage, and find the optimal balance between distribution and material costs.

David Volk, Head, Clinical Demand & Supply Planning at F. Hoffmann-La Roche

— They trust us —

quote-testimonials

otsuka

Otsuka
Supplies forecasting requires disciplined planning. This is made even more difficult when your study designs are extremely complicated. It was (and still may be) a common practice to plan for worst case scenarios to minimise risk. The CT-FAST tool allows us to perform re-evaluations, using IRT data from our ongoing studies, to generate targeted production plans for the future. CT-FAST allows us to escape the world of expensive worst case supplies planning while working with an acceptable level of risk for our company.

Jun Lee, clinical supplies project lead, Otsuka Pharmaceutical

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